Case Report: Non-bacterial thrombotic endocarditis and multiple thrombi uncover a hidden prothrombotic mutation - Takeaways - MDSpire

Case Report: Non-bacterial thrombotic endocarditis and multiple thrombi uncover a hidden prothrombotic mutation

  • By

  • Yongchao Luo

  • Lanlin Zhang

  • Xiang Zhang

  • Guotao Ma

  • July 7, 2026

  • 0 min

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  • 1

    Non-bacterial thrombotic endocarditis (NBTE) is a rare condition linked to hypercoagulable states, malignancy, or autoimmune diseases.

  • 2

    A 14-year-old male presented with severe abdominal pain and extensive thrombi, leading to a diagnosis of NBTE with tricuspid valve involvement.

  • 3

    Whole-exome sequencing identified a pathogenic variant in the F2 gene, confirming hereditary thrombophilia in the patient.

  • 4

    Surgical excision of the tricuspid valve vegetation and anticoagulation therapy resulted in complete resolution of symptoms.

  • 5

    At one-year follow-up, imaging showed recanalization of the portal and splenic veins without recurrent thrombosis.

Original Source(s)

Case Report: Non-bacterial thrombotic endocarditis and multiple thrombi uncover a hidden prothrombotic mutation

  • by Yongchao Luo, Lanlin Zhang, Xiang Zhang, Guotao Ma

  • July 7, 2026

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