Case report: Secretory carcinoma of the breast with ETV6-NTRK3 fusion: clinicopathological features and molecular confirmation by FISH in two cases - Takeaways - MDSpire

Case report: Secretory carcinoma of the breast with ETV6-NTRK3 fusion: clinicopathological features and molecular confirmation by FISH in two cases

  • By

  • Xiaoyu Sun

  • Jiaqi Liu

  • July 2, 2026

  • 0 min

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  • 1

    Secretory carcinoma of the breast (SCB) is a rare neoplasm, comprising less than 0.15% of all breast carcinomas.

  • 2

    Both reported cases exhibited triple-negative immunophenotype and confirmed ETV6-NTRK3 fusion via FISH analysis.

  • 3

    Case 1 had no nodal metastasis, while Case 2 presented with sentinel lymph node metastasis, highlighting variability in disease presentation.

  • 4

    Both patients underwent breast-conserving surgery and received adjuvant chemotherapy and radiation therapy without recurrence during follow-up.

  • 5

    The study emphasizes the importance of integrating morphology, immunohistochemistry, and molecular testing for accurate SCB diagnosis.

Original Source(s)

Case report: Secretory carcinoma of the breast with ETV6-NTRK3 fusion: clinicopathological features and molecular confirmation by FISH in two cases

  • by Xiaoyu Sun, Jiaqi Liu

  • July 2, 2026

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