Intensive versus standard statin therapy in acute ischemic stroke: a comparative study on the risk of pneumonia and multidrug-resistant bacterial infections

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The study analyzed 3,199 acute ischemic stroke patients to evaluate the effects of intensive versus standard atorvastatin therapy on post-stroke pneumonia.
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No significant difference in post-stroke pneumonia incidence was found between intensive (8.8%) and standard (8.3%) atorvastatin groups after propensity score matching.
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Multivariate regression analysis indicated that intensive atorvastatin treatment did not increase the risk of post-stroke pneumonia or multidrug-resistant infections.
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Among patients with post-stroke pneumonia, the severity and incidence of multidrug-resistant infections were similar between the two atorvastatin treatment groups.
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The findings suggest that high-intensity atorvastatin therapy does not elevate the risk of pneumonia or multidrug-resistant infections in acute ischemic stroke patients.

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