Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain - Takeaways - MDSpire

Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain

  • By

  • Calvin Wong

  • Luis David Rodriguez-Hernandez

  • Kevin C Lister

  • Ning Gu

  • Weihua Cai

  • Mehdi Hooshmandi

  • Jonathan Fan

  • Nicole Brown

  • Vivienne Nguyen

  • Alfredo Ribeiro-da-Silva

  • Robert P Bonin

  • Arkady Khoutorsky

  • August 21, 2024

  • 0 min

Share

  • 1

    Inhibition of spinal mTORC2 signaling alleviates both inflammatory and neuropathic pain symptoms in animal models.

  • 2

    Pharmacological activation of mTORC2 induces long-lasting pain hypersensitivity, highlighting its role in chronic pain.

  • 3

    Selective deletion of Rictor in excitatory neurons reduces inflammation-induced pain hypersensitivity and nerve injury effects.

  • 4

    Ablation of Rictor in inhibitory interneurons significantly reduces nerve injury-induced mechanical hypersensitivity.

  • 5

    The study identifies spinal mTORC2 as a potential therapeutic target for chronic pain, emphasizing its cell type-specific functions.

Original Source(s)

Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain

  • by Calvin Wong, Luis David Rodriguez-Hernandez, Kevin C Lister, Ning Gu, Weihua Cai, Mehdi Hooshmandi, Jonathan Fan, Nicole Brown, Vivienne Nguyen, Alfredo Ribeiro-da-Silva, Robert P Bonin, Arkady Khoutorsky

  • August 21, 2024

Related Content

Medical Oddities: Chew on This Cancer Prevention Idea

From gum to gut to memory—medicine gets weirdly clever fast 

Mapping ADHD Heterogeneity and Biotypes by Topological Deviations in Morphometric Similarity Networks

Head Trauma After Pressure Cooker Blast

Investigators describe a rare extradural hematoma requiring surgical evacuation.