Lead concentration in follicular fluid of infertile patients with and without endometriosis: a propensity score matching exploratory study - Takeaways - MDSpire

Lead concentration in follicular fluid of infertile patients with and without endometriosis: a propensity score matching exploratory study

  • By

  • Irene Iavarone

  • Daniela Mele

  • Francesca Caprio

  • Buenaventura Coroleu

  • Pasquale De Franciscis

  • Luigi Cobellis

  • Carlo Ronsini

  • May 22, 2026

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  • 1

    The study assessed lead concentrations in follicular fluid of infertile women with and without endometriosis undergoing IVF.

  • 2

    Follicular lead levels were significantly higher in women with endometriosis (2.07 µg/dL) compared to controls (0.63 µg/dL; p<0.001).

  • 3

    Logistic regression indicated a strong association between elevated lead levels and increased odds of endometriosis (OR: 14.6, p = 0.007).

  • 4

    In the endometriosis group, 30.8% had positive serum Beta-hCG after embryo transfer, but lead concentration variation was not statistically significant (p=0.12).

  • 5

    The findings suggest a potential link between lead exposure and endometriosis, warranting further investigation in larger studies.

Original Source(s)

Lead concentration in follicular fluid of infertile patients with and without endometriosis: a propensity score matching exploratory study

  • by Irene Iavarone, Daniela Mele, Francesca Caprio, Buenaventura Coroleu, Pasquale De Franciscis, Luigi Cobellis, Carlo Ronsini

  • May 22, 2026

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