Hyperhomocysteinemia promotes lipid deposition in skeletal muscle - Takeaways - MDSpire

Hyperhomocysteinemia promotes lipid deposition in skeletal muscle

  • By

  • Menghan Su

  • Jiaqi Jiao

  • Junsen Zhao

  • Jing Ma

  • Huiqiu Zhang

  • Qiyun Liu

  • Juan Wang

  • Dan Liu

  • Qi Wen

  • Jianli Wang

  • Xueli Chang

  • Junhong Guo

  • Wei Zhang

  • June 16, 2026

  • 0 min

Share

  • 1

    Lipid storage myopathy (LSM) is characterized by abnormal lipid accumulation in skeletal muscle, potentially triggered by environmental factors.

  • 2

    Hyperhomocysteinemia (HHcy) is linked to disrupted lipid metabolism and may contribute to abnormal lipid deposition in skeletal muscle.

  • 3

    In a study of six HHcy patients, all exhibited abnormal lipid deposition, with four showing clinical symptoms that resolved after B-vitamin supplementation.

  • 4

    Transcriptomic analysis revealed significant upregulation of the ACACB gene, leading to increased malonyl-CoA levels and impaired fatty acid oxidation.

  • 5

    The study concludes that HHcy correlates with increased ACC2 expression, which inhibits CPT1 activity, facilitating lipid accumulation in skeletal muscle.

Original Source(s)

Hyperhomocysteinemia promotes lipid deposition in skeletal muscle

  • by Menghan Su, Jiaqi Jiao, Junsen Zhao, Jing Ma, Huiqiu Zhang, Qiyun Liu, Juan Wang, Dan Liu, Qi Wen, Jianli Wang, Xueli Chang, Junhong Guo, Wei Zhang

  • June 16, 2026

Related Content

Surgical intervention versus conservative care in severe hypertensive pontine hemorrhage: a retrospective analysis of clinical outcomes

Exploratory identification of candidate biomarkers and molecular contributors to paclitaxel-induced peripheral neuropathy in patients with breast cancer through proteomic analysis

Adaptive deep brain stimulation for dynamic gait control in Parkinson’s disease: a randomized feasibility trial