CCL17 Influences Borrelia burgdorferi Infection in the Heart - Takeaways - MDSpire

CCL17 Influences Borrelia burgdorferi Infection in the Heart

  • By

  • Xiaotian Tang

  • Qian Yu

  • Yingjun Cui

  • Thomas M Hart

  • Freddie Rivas-Giorgi

  • Keith Calloway

  • Amrita Ray Mohapatra

  • Erol Fikrig

  • January 8, 2025

  • 0 min

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  • 1

    CCL17 knockout mice infected with Borrelia burgdorferi showed reduced pathogen load in cardiac tissue compared to control mice.

  • 2

    Infection with B. burgdorferi altered immune responses in CCL17 knockout mice, including changes in proinflammatory cytokine levels.

  • 3

    CCL17 directly interacts with Borrelia burgdorferi, marking the first evidence of a chemokine affinity for a vector-borne pathogen.

  • 4

    Lyme disease, caused by B. burgdorferi, is the most common vector-borne infection in North America, with over 40,000 cases annually.

  • 5

    CCL17 is implicated in modulating immune responses during B. burgdorferi infection, particularly in cardiac tissue.

Original Source(s)

CCL17 Influences Borrelia burgdorferi Infection in the Heart

  • by Xiaotian Tang, Qian Yu, Yingjun Cui, Thomas M Hart, Freddie Rivas-Giorgi, Keith Calloway, Amrita Ray Mohapatra, Erol Fikrig

  • January 8, 2025

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