Intravesical hyaluronic acid and chondroitin sulphate for recurrent urinary tract infections: a prospective multicentre comparison of two instillation protocols - Takeaways - MDSpire
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Comparative Analysis of Two Instillation Protocols of Intravesical Hyaluronic Acid and Chondroitin Sulphate for Women with Recurrent Urinary Tract Infections: A Prospective Multicenter Study

  • By

  • Marilena Gubbiotti

  • Alessandro Giammò

  • Enrico Ammirati

  • Annarita Cicalese

  • Elisabetta Costantini

  • Ester Illiano

  • Vincenzo Li Marzi

  • Mara Bacchiani

  • Leonardo Martino

  • Vito Mancini

  • Stefano Rosadi

  • September 7, 2026

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  • 1

    The study evaluated two intravesical instillation protocols of hyaluronic acid and chondroitin sulphate for women with recurrent urinary tract infections.

  • 2

    A total of 140 women participated, with 70 assigned to each of the two treatment groups over a 12-month follow-up period.

  • 3

    Both treatment groups showed significant improvements in urinary symptoms and UTI recurrence, with no serious adverse events reported.

  • 4

    Mean UTI frequency at 12 months was 0.6 episodes in Group A and 0.7 in Group B, with no significant intergroup difference.

  • 5

    The study highlights the lack of standardized protocols for intravesical GAG therapy despite its growing use in managing recurrent UTIs.

Original Source(s)

Intravesical hyaluronic acid and chondroitin sulphate for recurrent urinary tract infections: a prospective multicentre comparison of two instillation protocols

  • by Marilena Gubbiotti, Alessandro Giammò, Enrico Ammirati, Annarita Cicalese, Elisabetta Costantini, Ester Illiano, Vincenzo Li Marzi, Mara Bacchiani, Leonardo Martino, Vito Mancini, Stefano Rosadi

  • September 7, 2026

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