Efficacy and Safety of Immunotherapy in Head and Neck Tumors: A Systematic Review and Meta-Analysis of Clinical Outcomes and Survival Benefits - Takeaways - MDSpire

Efficacy and Safety of Immunotherapy in Head and Neck Tumors: A Systematic Review and Meta-Analysis of Clinical Outcomes and Survival Benefits

  • By

  • Qi, Chuang

  • Zhang, Xin

  • Guo, Hao

  • April 29, 2026

  • 0 min

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  • 1

    Immunotherapy shows moderate effectiveness in treating head and neck squamous cell carcinoma (HNSCC) with significant variability in clinical outcomes.

  • 2

    The analysis included 36 studies with a total of 8880 to 5930 patients, assessing various treatment outcomes.

  • 3

    Combination therapies yielded an improvement rate of 0.18, while dual/targeted immunotherapy achieved a superior rate of 0.22.

  • 4

    The PD-L1 biomarker is useful for predicting treatment response, though its performance is inconsistent across different applications.

  • 5

    The study highlights the need for further research to address publication bias and improve the reliability of real-world evidence in HNSCC.

Original Source(s)

Efficacy and Safety of Immunotherapy in Head and Neck Tumors: A Systematic Review and Meta-Analysis of Clinical Outcomes and Survival Benefits

  • by Qi, Chuang , Zhang, Xin , Guo, Hao

  • April 29, 2026

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