Nonsyndromic Agminated Basal Cell Carcinomas: Diagnostic and Therapeutic Conundrum Case Report - Takeaways - MDSpire
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Nonsyndromic Clusters of Basal Cell Carcinomas: A Diagnostic and Treatment Challenge in a Case Report

  • By

  • Sarita Pattisam

  • Kelly Kimball

  • Austin Cusick

  • Angela Casey

  • November 13, 2026

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  • 1

    Agminated basal cell carcinoma (BCC) describes multiple histologically confirmed BCCs developing in a discrete, localized skin region.

  • 2

    A 67-year-old woman developed 22 BCCs over 24 years, including 19 on the frontal scalp, without identified syndromic features or reported local exposures.

  • 3

    A 78-year-old man developed 44 BCCs over 11 years; 20 clustered in the right perioral and buccal region despite prior full-face acne radiation.

  • 4

    Both patients lacked associated syndromic stigmata, and nonsyndromic agminated BCC was diagnosed by exclusion; cutaneous mosaicism remains hypothetical.

  • 5

    Treatment for both patients combined electrodesiccation and curettage, Mohs micrographic surgery, and standard surgical excision.

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