A vitamin-biomarker risk score for 90-day functional outcome after acute ischemic stroke: development and internal validation in a retrospective cohort - Takeaways - MDSpire

A vitamin-biomarker risk score for 90-day functional outcome after acute ischemic stroke: development and internal validation in a retrospective cohort

  • By

  • Yang Xu

  • Pengfei He

  • Xue Kang

  • Peihui Liu

  • Changming Xu

  • May 29, 2026

  • 0 min

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  • 1

    The study evaluated the association between serum vitamin-related biomarkers and 3-month functional outcomes in acute ischemic stroke patients.

  • 2

    A total of 655 patients were included, with 52.82% experiencing poor outcomes defined as a modified Rankin Scale score of 3–6.

  • 3

    Vitamin D, E, A, K1, B12, folate, and homocysteine were identified as independent predictors of poor outcomes after multivariable analysis.

  • 4

    An internally validated nomogram was developed, showing good discrimination with AUC values of 0.878 in the training set and 0.880 in the test set.

  • 5

    The model requires external validation and prospective evaluation before it can be routinely used in clinical practice.

Original Source(s)

A vitamin-biomarker risk score for 90-day functional outcome after acute ischemic stroke: development and internal validation in a retrospective cohort

  • by Yang Xu, Pengfei He, Xue Kang, Peihui Liu, Changming Xu

  • May 29, 2026

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