Case Report: Trousseau syndrome presenting as multifocal cerebral infarctions in advanced gastric signet-ring cell carcinoma: tumor burden–driven hypercoagulability - Takeaways - MDSpire

Case Report: Trousseau syndrome presenting as multifocal cerebral infarctions in advanced gastric signet-ring cell carcinoma: tumor burden–driven hypercoagulability

  • By

  • Haocheng Zhao

  • Shanshan Lin

  • Wenye Huang

  • July 15, 2026

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  • 1

    Malignancy-associated hypercoagulability can lead to thromboembolic events, including ischemic stroke, despite anticoagulation.

  • 2

    A 76-year-old man with advanced gastric signet-ring cell carcinoma developed multiple cerebral infarcts and elevated D-dimer levels.

  • 3

    D-dimer levels remained high during anticoagulation treatment, indicating persistent coagulation activation.

  • 4

    Initiation of systemic chemotherapy correlated with a decline in D-dimer levels and improvement in neurological deficits.

  • 5

    The case highlights the relationship between tumor burden, coagulation markers, and the need for effective tumor-directed therapy.

Original Source(s)

Case Report: Trousseau syndrome presenting as multifocal cerebral infarctions in advanced gastric signet-ring cell carcinoma: tumor burden–driven hypercoagulability

  • by Haocheng Zhao, Shanshan Lin, Wenye Huang

  • July 15, 2026

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