Severe West Nile Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Infections in a Patient With Thymoma and Anti–Type I Interferon Antibodies

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A thymoma patient with anti-type I interferon autoantibodies experienced severe infections from West Nile virus and SARS-CoV-2.
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Genetic variants in TLR3 and CCR5 were identified, increasing susceptibility to severe COVID-19 and West Nile virus infections.
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Neutralizing autoantibodies against interferons were likely induced by the thymoma, impairing antiviral responses.
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The study highlights the importance of diagnosing underlying conditions in patients with severe viral infections.
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The findings suggest critical implications for the management of patients with combined genetic and autoimmune vulnerabilities.

The Journal Of Infectious Diseases

by Federica Barzaghi, Camilla Visconti, Giovanni Battista Pipitone, Simone Bondesan, Giulia Molli, Stefania Giannelli, Claudia Sartirana, Vito Lampasona, Elena Bazzigaluppi, Cristina Brigatti, Adrian Gervais, Paul Bastard, Chiara Tassan Din, Chiara Molinari, Lorenzo Piemonti, Jean-Laurent Casanova, Paola Carrera, Giorgio Casari, Alessandro Aiuti
July 8, 2024

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