Polyfunctional antibody signature defines protection in Andes hantavirus survival - Takeaways - MDSpire

Polyfunctional antibody signature defines protection in Andes hantavirus survival

  • By

  • Felipe Bravo

  • Tybbysay P. Salinas

  • Camila Kossack

  • Jorge T. Gonzalez

  • Israel Giacaman

  • Claudio Quevedo

  • Sebastián Fuller

  • Farides Saavedra

  • Claudio Aguilera-Pérez

  • Felipe Aguilera

  • Raúl Riquelme

  • María Luisa Rioseco

  • Mario Calvo

  • Raymond A. Alvarez

  • Juan Miguel Pascale

  • Blas Armién

  • Maritza Navarrete

  • Jose Luis Garrido

  • Maria Ines Barria

  • June 5, 2026

  • 0 min

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  • 1

    Andes orthohantavirus (ANDV) causes hantavirus cardiopulmonary syndrome (HCPS), characterized by high mortality rates of approximately 30-40%.

  • 2

    Survivors of acute HCPS exhibited elevated IgG and IgM responses against ANDV glycoproteins, particularly the GnGc complex.

  • 3

    Fc-mediated effector functions, including antibody-dependent NK cell activation and complement deposition, were significantly higher in patients with moderate disease.

  • 4

    Polyfunctional non-neutralizing IgG activities persisted for years in survivors, indicating a long-lasting immune response against ANDV.

  • 5

    The study highlights the importance of Fc effector functions as correlates of protection, informing future vaccine and therapeutic development against hantaviruses.

Original Source(s)

Polyfunctional antibody signature defines protection in Andes hantavirus survival

  • by Felipe Bravo, Tybbysay P. Salinas, Camila Kossack, Jorge T. Gonzalez, Israel Giacaman, Claudio Quevedo, Sebastián Fuller, Farides Saavedra, Claudio Aguilera-Pérez, Felipe Aguilera, Raúl Riquelme, María Luisa Rioseco, Mario Calvo, Raymond A. Alvarez, Juan Miguel Pascale, Blas Armién, Maritza Navarrete, Jose Luis Garrido, Maria Ines Barria

  • June 5, 2026

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