Clinical characteristics and risk factors of protein-losing enteropathy: a retrospective study - Takeaways - MDSpire

Clinical characteristics and risk factors of protein-losing enteropathy: a retrospective study

  • By

  • Wen-Tao Tan

  • Zi-Teng Wang

  • Hui Su

  • Chun-Mei Guo

  • Wen-Bin Shen

  • Hong Liu

  • May 8, 2026

  • 0 min

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  • 1

    The study analyzed 146 patients with protein-losing enteropathy (PLE) to compare connective tissue disease-associated PLE and lymphatic drainage disorder-associated PLE.

  • 2

    CTD-PLE patients were older, predominantly female, and exhibited higher D-dimer levels and thrombosis compared to LDD-PLE patients.

  • 3

    Distinct laboratory features were observed, with CTD-PLE showing higher cholesterol and globulin levels, while LDD-PLE had lower lymphocyte counts.

  • 4

    Age at onset, hemoglobin, and total cholesterol were identified as independent predictors for CTD-PLE, with a model showing good discrimination.

  • 5

    Follow-up data indicated that CTD-PLE patients responded better to glucocorticoids and immunosuppressants than LDD-PLE patients who underwent surgical treatment.

Original Source(s)

Clinical characteristics and risk factors of protein-losing enteropathy: a retrospective study

  • by Wen-Tao Tan, Zi-Teng Wang, Hui Su, Chun-Mei Guo, Wen-Bin Shen, Hong Liu

  • May 8, 2026

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