Impact of Olanzapine on Human Lipid Profiles: A Meta-Analysis of Randomized Controlled Trials Considering Time and Dosage Responses

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Olanzapine is an atypical antipsychotic associated with metabolic disturbances, particularly dyslipidemia, affecting lipid profiles.
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The drug has shown effectiveness in managing chemotherapy-induced nausea but raises concerns about its impact on lipid metabolism.
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Increased serum triglyceride levels are consistently reported in schizophrenia patients treated with olanzapine, but effects on cholesterol levels remain unclear.
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Dyslipidemia is a significant risk factor for cardiovascular disease, necessitating a better understanding of olanzapine's metabolic effects.
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This meta-analysis aims to quantify olanzapine's impact on lipid profiles by analyzing randomized controlled trials with a focus on time and dosage.

Bmc Cardiovascular Disorders

by Zhou Fang, Parmida Jamilian, Mohammad Safargar, Kousalya Prabahar, Liu Shuang
January 6, 2026

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