Sex differences in the association between relative Fat Mass and cognitive impairment in hospitalized middle-aged and older patients with type 2 diabetes mellitus in China: a single-center cross-sectional study - Takeaways - MDSpire

Sex differences in the association between relative Fat Mass and cognitive impairment in hospitalized middle-aged and older patients with type 2 diabetes mellitus in China: a single-center cross-sectional study

  • By

  • Yanting Liu

  • Yanlan Liu

  • Huina Qiu

  • Meiyun Zhang

  • Jingna Lin

  • February 3, 2026

  • 0 min

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  • 1

    Cognitive impairment prevalence is high among older individuals with type 2 diabetes, particularly affecting women and those with lower education.

  • 2

    Relative fat mass (RFM) is proposed as a more accurate measure of adiposity compared to BMI, linking obesity to various health conditions.

  • 3

    The relationship between adiposity and cognitive function varies by sex, with central obesity posing a higher risk for dementia in older women.

  • 4

    This study aims to explore the sex-specific association between RFM and cognitive impairment in hospitalized patients with type 2 diabetes.

  • 5

    Understanding the RFM and cognitive impairment relationship may help identify patients with type 2 diabetes at higher risk for cognitive decline.

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