The Sm29 antigen differentially shapes transcriptomic and regulatory landscapes across reactional forms of leprosy - Takeaways - MDSpire

The Sm29 antigen differentially shapes transcriptomic and regulatory landscapes across reactional forms of leprosy

  • By

  • Joyce Karoline Silva

  • Lucas Neves de Farias

  • Tainã Lago

  • Luciana dos Santos Cardoso

  • Ricardo Khouri

  • Paulo Roberto Machado

  • Léa Cristina Castellucci

  • June 1, 2026

  • 0 min

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  • 1

    The study investigates the immunomodulatory effects of the Schistosoma mansoni Sm29 antigen on leprosy patients.

  • 2

    Sm29 antigen modulates immune response pathways, particularly in reactional forms of leprosy, such as reversal reaction and erythema nodosum leprosum.

  • 3

    Differential expression analysis identified specific genes that are more expressed in reversal reaction compared to erythema nodosum leprosum.

  • 4

    The modulation of immune responses by Sm29 includes increased IL-10 levels and changes in chemokine and cytokine profiles.

  • 5

    This research provides insights into the potential of Sm29 for regulating inflammatory responses in leprosy.

Original Source(s)

The Sm29 antigen differentially shapes transcriptomic and regulatory landscapes across reactional forms of leprosy

  • by Joyce Karoline Silva, Lucas Neves de Farias, Tainã Lago, Luciana dos Santos Cardoso, Ricardo Khouri, Paulo Roberto Machado, Léa Cristina Castellucci

  • June 1, 2026

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