A study identified hundreds of genes linked to Alzheimer's disease in African American brain tissue, addressing a gap in neurodegenerative research.
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Researchers analyzed RNA sequencing data from 207 African American donors, revealing 482 genes with significant expression differences related to Alzheimer's.
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The gene ADAMTS2 was most strongly associated with Alzheimer's, showing higher expression in affected individuals and linking to neurological pathways.
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The study found altered gene expression patterns related to energy metabolism, particularly in mitochondrial function, supporting previous research on neurodegeneration.
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Findings highlight the importance of diverse cohorts in Alzheimer's research, revealing both shared and unique molecular features across populations.
