Case Report: Aplastic anemia associated with parvovirus B19 infection following neoadjuvant pembrolizumab-based chemoimmunotherapy for triple-negative breast cancer - Takeaways - MDSpire

Case Report: Aplastic anemia associated with parvovirus B19 infection following neoadjuvant pembrolizumab-based chemoimmunotherapy for triple-negative breast cancer

  • By

  • Jan Kindl

  • Dominika Svobodová

  • Martin Matějů

  • Martina Zimovjanová

  • Michal Vočka

  • Petra Kovaříková

  • Zuzana Bielčiková

  • July 10, 2026

  • 0 min

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  • 1

    A 54-year-old woman with triple-negative breast cancer developed severe pancytopenia after neoadjuvant pembrolizumab and chemotherapy.

  • 2

    Bone marrow biopsy indicated generalized bone marrow suppression, raising suspicion for immune-related hematologic toxicity.

  • 3

    Further testing revealed a parvovirus B19 infection, leading to the initiation of intravenous immunoglobulin therapy.

  • 4

    The patient experienced rapid hematologic recovery after treatment, and pembrolizumab was discontinued.

  • 5

    At 20 months follow-up, the patient remained free of disease recurrence, highlighting the need for careful diagnostic evaluation.

Original Source(s)

Case Report: Aplastic anemia associated with parvovirus B19 infection following neoadjuvant pembrolizumab-based chemoimmunotherapy for triple-negative breast cancer

  • by Jan Kindl, Dominika Svobodová, Martin Matějů, Martina Zimovjanová, Michal Vočka, Petra Kovaříková, Zuzana Bielčiková

  • July 10, 2026

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