Editorial: Host-microbe immunometabolic chat: a new era of organismal communication - Takeaways - MDSpire

Editorial: Host-microbe immunometabolic chat: a new era of organismal communication

  • By

  • Marco Gargaro

  • Francesca Fallarino

  • Teresa Zelante

  • May 29, 2026

  • 0 min

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  • 1

    Microbiota regulates host physiology through metabolic, immune, and neuroimmune interactions, influencing immune homeostasis and disease susceptibility.

  • 2

    Microbial signals affect distant tissues systemically, indicating that immune regulation arises from interactions among microbial metabolites and host pathways.

  • 3

    Research highlights that microbiota composition mainly facilitates communication through metabolic pathways rather than directly impacting physiology.

  • 4

    Microbiota-derived metabolites, such as short-chain fatty acids, play a crucial role in inflammation and recovery from tissue necrosis.

  • 5

    Emerging evidence suggests that neuroimmune interactions and microbiota-derived metabolites may influence neuropsychiatric disorders and immune signaling.

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