The mechanism of gut microbiota in septic cardiomyopathy based on the bulk transcriptome and Mendelian randomization analysis - Takeaways - MDSpire

The mechanism of gut microbiota in septic cardiomyopathy based on the bulk transcriptome and Mendelian randomization analysis

  • By

  • Yuxia Tao

  • Lianxin Li

  • Jianhao Wang

  • Wenting Du

  • Shan Ye

  • Jinshuai Lu

  • May 4, 2026

  • 0 min

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  • 1

    Septic cardiomyopathy (SCM) is a serious complication of sepsis, characterized by ventricular dilatation and impaired contractility.

  • 2

    The study identified STAT3 and SLC5A1 as candidate biomarkers associated with gut microbiota in SCM.

  • 3

    Mendelian randomization analysis revealed five key gut microbiota and 22 metabolites potentially involved in septic complications.

  • 4

    Clinical validation showed elevated serum IL-6 and cTnI levels in SCM patients, while propylene glycol levels were decreased.

  • 5

    The findings provide a foundation for future investigations into the mechanistic roles of gut microbiota in SCM development.

Original Source(s)

The mechanism of gut microbiota in septic cardiomyopathy based on the bulk transcriptome and Mendelian randomization analysis

  • by Yuxia Tao, Lianxin Li, Jianhao Wang, Wenting Du, Shan Ye, Jinshuai Lu

  • May 4, 2026

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