Intraoperative functional brain mapping for glioma surgery: a comprehensive review of the University of California San Francisco mapping protocol - Takeaways - MDSpire

Intraoperative functional brain mapping for glioma surgery: a comprehensive review of the University of California San Francisco mapping protocol

  • By

  • Jia-Shu Chen

  • Brandon Bergsneider

  • Alexander F. Haddad

  • Ramin A. Morshed

  • Shawn L. Hervey-Jumper

  • Jacob S. Young

  • Mitchel S. Berger

  • June 13, 2026

  • 0 min

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  • 1

    Maximal glioma resection aims to remove tumor while preserving neurological function, with evolving standards for safe resection boundaries.

  • 2

    Intraoperative brain mapping significantly reduces neurological deficits and improves surgical outcomes, including overall survival and quality of life.

  • 3

    The UCSF protocol utilizes awake language mapping and asleep motor mapping techniques to enhance surgical precision and patient comfort.

  • 4

    Preoperative imaging with DTI and MEG is essential for accurate localization of functional brain areas, improving surgical planning and outcomes.

  • 5

    MEG is more effective than fMRI in localizing functional cortex, providing real-time brain function data critical for intraoperative mapping.

Original Source(s)

Intraoperative functional brain mapping for glioma surgery: a comprehensive review of the University of California San Francisco mapping protocol

  • by Jia-Shu Chen, Brandon Bergsneider, Alexander F. Haddad, Ramin A. Morshed, Shawn L. Hervey-Jumper, Jacob S. Young, Mitchel S. Berger

  • June 13, 2026

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