Link Between Plasma Aldosterone Levels and Cardiovascular Disease Risk in Patients with Hypertension: A Cohort Analysis

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This study evaluated the association between plasma aldosterone concentration (PAC) and cardiovascular disease (CVD) risk in hypertensive patients.
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A total of 8653 hypertensive patients were analyzed, with a median follow-up of 5.2 years, resulting in 737 incident CVD cases.
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Higher PAC levels were linked to increased CVD risk, with the highest quartile showing a 51% increased risk compared to the lowest quartile.
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The association between PAC and CVD risk remained consistent across stratification and sensitivity analyses.
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Findings suggest that PAC may serve as a target for early prevention of cardiovascular events in hypertensive patients.

Frontiers In Endocrinology

by Lin Gan, Nanfang Li, Mulalibieke Heizhati, Hui Wang, Ling Yao, Li Cai, Shasha Liu, Jing Hong, Delian Zhang
April 23, 2026

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