Dynamic changes of Kisspeptin during controlled ovarian hyperstimulation (COH) in polycystic ovary syndrome patients and its correlation with COH outcomes

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Kisspeptin levels were significantly higher in PCOS patients during controlled ovarian hyperstimulation compared to controls.
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Higher Kisspeptin levels correlated positively with ovarian reserve markers but negatively with top-quality embryo rates.
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PCOS patients had more retrieved oocytes and embryos but lower cumulative pregnancy and live birth rates than controls.
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Serum Kisspeptin levels on the day of oocyte pickup showed predictive value for pregnancy outcomes in PCOS patients.
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The study highlights Kisspeptin's potential role in understanding reproductive dysfunction and optimizing treatment in PCOS.

Frontiers In Endocrinology

by Lu Han, Yiran Wang, Yueying Li, Xiaoyan Li, Jing Zhang, Yan Zhang, Mingfei Zhao, Haixia Chen, Huiying Zhang, Yingmei Wang, Fengxia Xue, Wenyan Tian
May 20, 2026

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