Impact of Cannabis Edibles Combined With Alcohol on Driving, Field Sobriety Performance, and Subjective

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Co-use of cannabis edibles and alcohol increases the risk of motor vehicle accidents and impairs driving ability more than using either substance alone.
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Previous studies primarily focused on inhaled cannabis, leaving a gap in understanding the effects of cannabis edibles combined with alcohol.
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The study utilized a double-blind, crossover design to assess the impact of different THC doses and alcohol concentrations on driving performance.
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Participants were healthy adults aged 21-55 with recent binge drinking experience, ensuring a relevant sample for studying co-use effects.
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The research aims to clarify the pharmacokinetic interactions between cannabis edibles and alcohol, informing public safety and driving regulations.

Jama Network Open

by C. Austin Zamarripa, Spencer Lin, McKenna Klausner, Kriti Rastogi, Daniel J. O. Roche, Matthew Novak, Denis Antoine, David Wolinsky, Thomas D. Marcotte, Elise M. Weerts, Ryan Vandrey, Tory R. Spindle
May 1, 2026

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