Coordinated Signaling Pathways in Airway Epithelium Connect Allergen-Induced Inflammation to Structural Changes in Asthma

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Asthma is a chronic inflammatory airway disease characterized by immune activation, airway hyperresponsiveness, and structural remodeling.
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The airway epithelium orchestrates immune responses and drives structural changes through various signaling pathways upon allergen exposure.
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Asthma exhibits immunological heterogeneity, with T2-high eosinophilic and T2-low neutrophilic or mixed endotypes influencing treatment responses.
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The airway epithelium is an active regulator of immune responses, exhibiting intrinsic abnormalities that lower the threshold for allergen-induced inflammation.
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Integrated epithelial signaling networks, rather than single-pathway models, are crucial for understanding asthma pathogenesis and treatment challenges.

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