Sympathetic ophthalmia complicating proliferative diabetic retinopathy: diagnostic and therapeutic challenges during pregnancy - Takeaways - MDSpire
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Complications of Sympathetic Ophthalmia in Pregnant Patients with Proliferative Diabetic Retinopathy: Diagnostic and Treatment Challenges

  • By

  • Norah Alshabib

  • Motazz Alarfaj

  • Abdullah Albahlal

  • Nora A. Alyousif

  • August 24, 2026

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  • 1

    Sympathetic ophthalmia (SO) is a rare bilateral granulomatous panuveitis following ocular trauma or surgery, with an incidence of 0.1% after surgery and 0.2–0.5% after trauma.

  • 2

    Patients with both sympathetic ophthalmia and proliferative diabetic retinopathy (PDR) may experience more complications and worse visual outcomes than those with PDR alone.

  • 3

    A case study described a 27-year-old woman with poorly controlled type 1 diabetes who developed SO after penetrating trauma, leading to significant visual decline.

  • 4

    Treatment for SO included high-dose intravenous methylprednisolone and adalimumab to manage inflammation and reduce corticosteroid exposure during pregnancy.

  • 5

    Following treatment, the patient's visual acuity improved, and both SO and PDR showed regression, although complications persisted during a subsequent pregnancy.

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