Huangjin Shuangshen decoction alleviates chronic atrophic gastritis by suppressing TNF/NF-κB signaling and promoting CFTR-associated gastric mucosal barrier repair

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Huangjin Shuangshen Decoction (HJSS) mitigates chronic atrophic gastritis (CAG) by reducing inflammatory injury and enhancing gastric mucosal barrier recovery.
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HJSS treatment improved gastric function, reduced inflammation, and attenuated apoptosis-related epithelial injury in experimental CAG models.
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The study identified that HJSS promotes recovery of barrier-associated molecules such as CFTR, ZO-1, MUC5AC, Occludin, and Claudin-1.
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HJSS was associated with the suppression of TNF/NF-κB signaling and reduced nuclear translocation of p65, indicating its anti-inflammatory effects.
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The research utilized a combination of in vivo and in vitro methods, including transcriptomic analysis and network pharmacology, to explore HJSS mechanisms.

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