The “two flowers therapy”: clinical efficacy and mechanisms of a total glucosides of paeony -colchicine dual-drugs for Behçet’s disease derived from Chinese physicians’ medication experience - Takeaways - MDSpire

Efficacy and Mechanisms of the Dual-Drug Approach Using Total Glucosides of Paeony and Colchicine for Treating Behçet’s Disease: Insights from Chinese Medical Practice

  • By

  • Can Liu

  • Lei Li

  • Qinlong Sun

  • Yixuan Zhang

  • Siyao Li

  • Jian-long Guan

  • Jianfei Cai

  • July 21, 2026

Share

  • 1

    The study investigates the efficacy and mechanisms of a dual-drug regimen combining Total Glucosides of Paeony and colchicine for Behçet’s disease.

  • 2

    A retrospective cohort study involved 355 Behçet’s disease patients, comparing a combination group and a monotherapy group.

  • 3

    Core targets identified include MMP9, ICAM1, FGF2, TLR4, EGFR, and NOS3, with significant molecular docking results confirming high affinity.

  • 4

    The combination group showed superior early efficacy in reducing oral and genital ulcer prevalence compared to the monotherapy group.

  • 5

    Both treatment groups achieved complete ulcer resolution by M3, with the combination group experiencing transient diarrhea but no cytopenia.

Original Source(s)

The “two flowers therapy”: clinical efficacy and mechanisms of a total glucosides of paeony -colchicine dual-drugs for Behçet’s disease derived from Chinese physicians’ medication experience

  • by Can Liu, Lei Li, Qinlong Sun, Yixuan Zhang, Siyao Li, Jian-long Guan, Jianfei Cai

  • July 21, 2026

Related Content

Current status and research gaps of neuromodulation in the rehabilitation of knee osteoarthritis: a scoping review

Biomarker patterns across skin–lung–gut burden in systemic sclerosis

A transfer learning-based multimodal model for early prediction of 90-day respiratory failure in dermatomyositis-associated interstitial lung disease