Early divergence of treatment response trajectories to adalimumab or its biosimilar in active ankylosing spondylitis: consensus clustering analysis of a randomized controlled trial - Takeaways - MDSpire

Early divergence of treatment response trajectories to adalimumab or its biosimilar in active ankylosing spondylitis: consensus clustering analysis of a randomized controlled trial

  • By

  • Zhiqiang Zhong

  • Hongjuan Lu

  • Ting Li

  • Lingying Ye

  • Ling Zhou

  • Xiaobing Wang

  • Xin Wu

  • Huji Xu

  • June 23, 2026

  • 0 min

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  • 1

    A study analyzed treatment responses to adalimumab and its biosimilar in 438 patients with active ankylosing spondylitis over 24 weeks.

  • 2

    Two clusters emerged: a favorable-response cluster (C1) with 56.2% of patients and a less favorable-response cluster (C2) with 43.8%.

  • 3

    Cluster C2 was characterized by older age, longer disease duration, and more prior TNFi exposure compared to cluster C1.

  • 4

    Significant divergence in clinical endpoints between clusters was observed as early as week 2 and sustained through week 24.

  • 5

    A multivariable model achieved a C-statistic of 0.880 for predicting cluster membership based on baseline and week-2 data.

Original Source(s)

Early divergence of treatment response trajectories to adalimumab or its biosimilar in active ankylosing spondylitis: consensus clustering analysis of a randomized controlled trial

  • by Zhiqiang Zhong, Hongjuan Lu, Ting Li, Lingying Ye, Ling Zhou, Xiaobing Wang, Xin Wu, Huji Xu

  • June 23, 2026

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