The Impact of Adolescent Cannabis Consumption on Brain Development: A Systematic Review - Takeaways - MDSpire

The Impact of Adolescent Cannabis Consumption on Brain Development: A Systematic Review

  • By

  • Valerio Ricci

  • Alessandro Sarni

  • Domenico De Berardis

  • Giovanni Martinotti

  • Giuseppe Maina

  • April 27, 2026

  • 0 min

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  • 1

    Adolescent cannabis use is linked to structural brain changes, including reduced prefrontal cortical and hippocampal volumes.

  • 2

    Cognitive effects of adolescent cannabis use are mixed, with some users experiencing persistent deficits after prolonged abstinence.

  • 3

    Epidemiological studies indicate a significantly elevated addiction risk in adolescents compared to adults, with odds ratios ranging from 3.9 to 7.2.

  • 4

    Long-term consequences of adolescent cannabis use include educational difficulties, mental health issues, and functional impairments.

  • 5

    Methodological limitations in existing studies hinder causal inference, emphasizing the need for rigorous longitudinal research.

Original Source(s)

The Impact of Adolescent Cannabis Consumption on Brain Development: A Systematic Review

  • by Valerio Ricci, Alessandro Sarni, Domenico De Berardis, Giovanni Martinotti, Giuseppe Maina

  • April 27, 2026

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