Dosimetric Evaluation of Two Multileaf Collimator Systems in Simultaneous Integrated Boost Volumetric Modulated Arc Therapy for Stage IIIC Cervical Cancer with Lymph Node Metastases

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The study evaluated dosimetric performance of two multileaf collimator systems in SIB-VMAT for stage IIIC cervical cancer with lymph node metastases.
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Both MLC systems achieved clinically acceptable target coverage across all lymph node metastasis subgroups in the study.
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The α-MLC system showed improved dose gradient control for the planning target volume, particularly in bilateral pelvic lymph node metastases.
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The α-MLC system consistently reduced doses to organs at risk compared to the p-MLC system, enhancing patient safety.
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These findings may guide equipment selection and planning strategies in challenging nodal boost scenarios for advanced cervical cancer.

Frontiers In Oncology

by Hui Xiao, Ang Qu, Haitao Sun, Xile Zhang, Nan Zhang, Shuhua Wei, Xiuwen Deng, Chunxiao Li, Junjie Wang, Ping Jiang
April 23, 2026

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