Troponin for surveillance of immune checkpoint inhibitor–associated myocarditis and post-therapy cardiovascular risk stratification: a systematic review and meta-analysis - Takeaways - MDSpire

Troponin for surveillance of immune checkpoint inhibitor–associated myocarditis and post-therapy cardiovascular risk stratification: a systematic review and meta-analysis

  • By

  • Ahmed J. Alaraibi

  • Mustafa Alani

  • Layla Al-Nooh

  • Nairouz Quateen

  • Lulwa Al-Qallaf

  • Retaj Al-Azemi

  • Mohammed Taqi

  • Abdullatif Alfehaid

  • Paul Murray

  • June 26, 2026

  • 0 min

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  • 1

    Immune checkpoint inhibitors (ICIs) can cause myocarditis, a serious complication with high morbidity and mortality.

  • 2

    Cardiac troponin is a biomarker used to identify myocardial injury and is increasingly utilized in cardio-oncology.

  • 3

    Troponin elevation is associated with confirmed ICI-associated myocarditis, but false positives are common.

  • 4

    Elevated troponin levels correlate with increased risk of major adverse cardiovascular events and mortality.

  • 5

    Troponin should not be used as a standalone diagnostic test due to variability in performance and common false positives.

Original Source(s)

Troponin for surveillance of immune checkpoint inhibitor–associated myocarditis and post-therapy cardiovascular risk stratification: a systematic review and meta-analysis

  • by Ahmed J. Alaraibi, Mustafa Alani, Layla Al-Nooh, Nairouz Quateen, Lulwa Al-Qallaf, Retaj Al-Azemi, Mohammed Taqi, Abdullatif Alfehaid, Paul Murray

  • June 26, 2026

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