Hydrogen sulfide donor sodium hydrosulfide modulates ovarian steroidogenesis and follicular integrity in a DHEA-induced rat model of polycystic ovary syndrome

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Sodium hydrosulfide (NaHS) was studied for its effects on ovarian steroidogenesis and follicle health in a rat model of polycystic ovary syndrome (PCOS).
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PCOS was induced in rats using daily subcutaneous injections of dehydroepiandrosterone (DHEA) for 20 days, leading to disrupted estrous cyclicity and altered hormone levels.
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NaHS administration improved estrous cyclicity, reduced follicular damage and apoptosis, and modulated the expression of steroidogenic and H2S-producing enzymes.
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DHEA treatment resulted in increased cystic and atretic follicles, elevated apoptotic activity, and altered expression of key steroidogenic enzymes.
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The study suggests a potential regulatory interaction between hydrogen sulfide pathways and ovarian dysfunction in PCOS, warranting further investigation.

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