Shortening of central venous catheter time in men with hematological and oncological diseases for prevention of central venous catheter-related bloodstream infections: a target-trial-emulation study

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Bloodstream infections are more common in patients with hematological malignancies and men have higher susceptibility and mortality rates.
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Central venous catheters are a significant source of catheter-related bloodstream infections in cancer patients.
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A propensity score-matched study indicated that male sex is an independent risk factor for catheter-related bloodstream infections.
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The study utilized a target-trial-emulation approach to simulate earlier removal of central venous catheters in male patients.
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The overall catheter-related bloodstream infection rate was similar between the experimental and control groups after simulation.

Infection

by Oliver Kriege, Boris Böll, Nicole Brüder, Nicola Giesen, Julia Lanznaster, Susanne Mertins, Antrea Minti, Jan-Hendrik Naendrup, Martin Schmidt-Hieber, Ruth Seggewiss-Bernhardt, Philipp Weber, Kai Wille, Jens Panse, Marcus Hentrich, Enrico Schalk
July 10, 2026

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