Borderline Liver Enzyme Patterns and Their Metabolic–Inflammatory Signatures: An Observational Outpatient Study - Takeaways - MDSpire

Borderline Liver Enzyme Patterns and Their Metabolic–Inflammatory Signatures: An Observational Outpatient Study

  • By

  • Özdemir, Erdoğan

  • Yılmaz, Turgay

  • April 30, 2026

  • 0 min

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  • 1

    Borderline liver enzyme elevations are common in outpatient settings and may indicate distinct metabolic and inflammatory profiles.

  • 2

    In a study of 800 adults, 26.4% had borderline liver enzyme elevations, with 49.8% showing a hepatocellular pattern.

  • 3

    The hepatocellular pattern was linked to higher ferritin and lower AST/ALT ratios, with ferritin as the only independent correlate.

  • 4

    The cholestatic pattern was associated with higher HbA1c and systemic immune-inflammation index, with HbA1c as a key predictor.

  • 5

    Applying sex-specific reference ranges allows for stratification of borderline liver enzyme elevations into clinically relevant subphenotypes.

Original Source(s)

Borderline Liver Enzyme Patterns and Their Metabolic–Inflammatory Signatures: An Observational Outpatient Study

  • by Özdemir, Erdoğan , Yılmaz, Turgay

  • April 30, 2026

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