Associations of FGF23 and Apelin-13 with osteoporosis and diabetic peripheral neuropathy in postmenopausal women with type 2 diabetes mellitus - Takeaways - MDSpire

Associations of FGF23 and Apelin-13 with osteoporosis and diabetic peripheral neuropathy in postmenopausal women with type 2 diabetes mellitus

  • By

  • Yue Kong

  • Fan Zuo

  • Xuxiang Zhang

  • Zhao Xu

  • Yudi Hu

  • Xin Nian

  • May 11, 2026

  • 0 min

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  • 1

    FGF23 and Apelin-13 levels are correlated with osteoporosis and diabetic peripheral neuropathy in postmenopausal women with type 2 diabetes mellitus.

  • 2

    Higher levels of Apelin-13 and 25OH-VitD are protective against osteoporosis, while elevated FGF23 and PTH are risk factors.

  • 3

    A predictive model combining diabetes duration, estrogen levels, CPT scores, FGF23, and Apelin-13 shows high accuracy for osteoporosis risk.

  • 4

    Lower bone mineral density T-scores are significantly associated with increased risk of diabetic peripheral neuropathy.

  • 5

    The study suggests that FGF23 and Apelin-13 may serve as potential targets for future research on osteoporosis and diabetic peripheral neuropathy.

Original Source(s)

Associations of FGF23 and Apelin-13 with osteoporosis and diabetic peripheral neuropathy in postmenopausal women with type 2 diabetes mellitus

  • by Yue Kong, Fan Zuo, Xuxiang Zhang, Zhao Xu, Yudi Hu, Xin Nian

  • May 11, 2026

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