Peripheral blood CADM1 expression and multi-gene signatures in depressive disorders: a pilot case-control study from the United Arab Emirates

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This study investigated gene expression of seven candidate genes in adults with depressive disorders in the UAE.
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CADM1 showed modest upregulation in the depressive disorder group but did not survive multiple testing correction.
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Principal component analysis indicated an unadjusted difference driven by CADM1 and RAPH1, which attenuated after age adjustment.
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The CADM1 area under the receiver operating characteristic curve was 0.616, indicating no diagnostic utility.
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This pilot study provides preliminary data on gene expression in depression but requires validation in larger, age-matched studies.

Frontiers In Psychiatry

by Rukhsana Nawaz, Eman Al Awadhi, Fadwa Al Mughairbi, Asma Bashir, Gabriel Andrade, Syed Ali Bokhari, Syed Fahad Javaid, Abdalla A. R. M. Hamid
July 1, 2026

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