Dysregulated lipid metabolites GML and GMO were associated with cytotoxic T cell function and serve as biomarkers for acute pulmonary embolism - Takeaways - MDSpire

Dysregulated lipid metabolites GML and GMO were associated with cytotoxic T cell function and serve as biomarkers for acute pulmonary embolism

  • By

  • Tongyao Guo

  • Weibo Gao

  • Aimin Zhang

  • Dong Wang

  • Yushang Zhao

  • Yining Li

  • Zhihong Yue

  • Lin Pei

  • Mei Jia

  • Chen Liu

  • Lin-Lin Cao

  • July 8, 2026

  • 0 min

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  • 1

    The study identified serum lipid biomarkers GML and GMO that are elevated in acute pulmonary embolism (APE) compared to healthy controls.

  • 2

    Pseudotargeted lipidomics revealed 203 upregulated and 57 downregulated serum lipids in APE patients.

  • 3

    GML and GMO levels correlated with clinical risk stratification and demonstrated high sensitivity and specificity as diagnostic markers for APE.

  • 4

    Cytotoxic T cells from APE patients showed decreased expression of granzyme B, perforin, and granulysin.

  • 5

    In vitro experiments indicated that GML and GMO impair cytotoxic T cell function by downregulating Notch1 signaling and cytotoxic proteins.

Original Source(s)

Dysregulated lipid metabolites GML and GMO were associated with cytotoxic T cell function and serve as biomarkers for acute pulmonary embolism

  • by Tongyao Guo, Weibo Gao, Aimin Zhang, Dong Wang, Yushang Zhao, Yining Li, Zhihong Yue, Lin Pei, Mei Jia, Chen Liu, Lin-Lin Cao

  • July 8, 2026

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