Hemodynamic evaluation following ductal closure and association with IVH in premature infants born at 22–23weeks gestation - Takeaways - MDSpire

Hemodynamic evaluation following ductal closure and association with IVH in premature infants born at 22–23weeks gestation

  • By

  • Tomonori Kurimoto

  • Katsuaki Toyoshima

  • Hiroshi Ohashi

  • Jun Shibasaki

  • Tomoyuki Shimokaze

  • Tomoko Saito

  • Kaoru Katsumata

  • Asataro Yara

  • Eiji Hirakawa

  • Takuya Tokuhisa

  • June 12, 2026

  • 0 min

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  • 1

    This study assessed hemodynamic changes post-ductal closure in infants born at 22–23 weeks gestation and their relationship with intraventricular hemorrhage (IVH).

  • 2

    Twenty-six infants were included, with seven developing grade 2–4 IVH detected after patent ductus arteriosus (PDA) closure, while 19 did not develop IVH.

  • 3

    Infants with IVH exhibited increased end-systolic wall stress, mean arterial pressure, and heart rate, alongside decreased mean velocity of circumferential fiber shortening post-closure.

  • 4

    Significant between-group differences in hemodynamic parameters were observed at 6 and 12 hours after ductal closure (all p < 0.01).

  • 5

    The findings indicate that hemodynamic instability within 12 hours after ductal closure is associated with subsequent IVH in extremely preterm infants.

Original Source(s)

Hemodynamic evaluation following ductal closure and association with IVH in premature infants born at 22–23weeks gestation

  • by Tomonori Kurimoto, Katsuaki Toyoshima, Hiroshi Ohashi, Jun Shibasaki, Tomoyuki Shimokaze, Tomoko Saito, Kaoru Katsumata, Asataro Yara, Eiji Hirakawa, Takuya Tokuhisa

  • June 12, 2026

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