Environmental Nonessential Element Exposure and Urologic Cancer: A Systematic Review and Meta-Analysis - Takeaways - MDSpire

Environmental Nonessential Element Exposure and Urologic Cancer: A Systematic Review and Meta-Analysis

  • By

  • Zhengyi Deng

  • Jinhui Li

  • Renyue Ji

  • Juan Ramon Delgado

  • Steve H. L. Yim

  • Linda Kachuri

  • Andres Cardenas

  • Rebecca E. Graff

  • John T. Leppert

  • Leslie K. Dennis

  • Benjamin I. Chung

  • Marvin E. Langston

  • May 22, 2026

  • 0 min

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  • 1

    Urologic cancers account for 13.1% of new cancer cases and 7.9% of cancer deaths globally, with prostate, kidney, and bladder cancers being the most common.

  • 2

    Inherited genetic predisposition accounts for 30% to 60% of urologic cancer cases, while a significant portion of risk is attributed to environmental and lifestyle factors.

  • 3

    Nonessential elements like arsenic and cadmium are classified as group 1 carcinogens and are linked to increased risks of kidney, prostate, and bladder cancers.

  • 4

    The study conducted a systematic review and meta-analysis to evaluate the associations between multiple nonessential elements and urologic cancer risk.

  • 5

    Meta-analyses included studies assessing arsenic, cadmium, vanadium, nickel, lead, and chromium, focusing on their effects on various urologic cancer types.

Original Source(s)

Environmental Nonessential Element Exposure and Urologic Cancer: A Systematic Review and Meta-Analysis

  • by Zhengyi Deng, Jinhui Li, Renyue Ji, Juan Ramon Delgado, Steve H. L. Yim, Linda Kachuri, Andres Cardenas, Rebecca E. Graff, John T. Leppert, Leslie K. Dennis, Benjamin I. Chung, Marvin E. Langston

  • May 22, 2026

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