Physeal breach as a potential predictor of pulmonary metastasis in paediatric osteosarcoma - Takeaways - MDSpire

Physeal breach as a potential predictor of pulmonary metastasis in paediatric osteosarcoma

  • By

  • Zichen Lin

  • Peng Huang

  • Jing Shan

  • Zhi Qi

  • Miaoyang Liang

  • Bixuan Cao

  • Bo Ning

  • May 5, 2026

  • 0 min

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  • 1

    Osteosarcoma is the most common primary malignant bone tumor in adolescents, with pulmonary metastasis being the leading cause of death.

  • 2

    In a study of 32 pediatric osteosarcoma patients, physeal breach was identified as the only independent predictor of pulmonary metastasis.

  • 3

    Pulmonary metastases were present in 22% of patients at diagnosis and increased to 50% by the last follow-up.

  • 4

    In an orthotopic xenograft model, all mice with physeal breach developed pulmonary metastases, while none in the non-breach group did.

  • 5

    Physeal breach may serve as a practical biomarker for risk stratification and predicting pulmonary metastasis in pediatric osteosarcoma.

Original Source(s)

Physeal breach as a potential predictor of pulmonary metastasis in paediatric osteosarcoma

  • by Zichen Lin, Peng Huang, Jing Shan, Zhi Qi, Miaoyang Liang, Bixuan Cao, Bo Ning

  • May 5, 2026

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