Rapid evaporative ionization mass spectrometry in surgery: a systematic review - Takeaways - MDSpire

Rapid evaporative ionization mass spectrometry in surgery: a systematic review

  • By

  • Angus R J Barber

  • Alexander Dottore

  • James Leigh

  • Mark Fear

  • Fiona Wood

  • November 12, 2025

  • 0 min

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  • 1

    Rapid evaporative ionization mass spectrometry (REIMS) enables real-time tissue identification during surgical procedures.

  • 2

    A systematic review identified 26 studies across seven countries, focusing on REIMS applications in eight surgical specialties.

  • 3

    Most studies reported REIMS effectiveness in identifying cancerous tissue, demonstrating promising accuracy, sensitivity, and specificity.

  • 4

    Current limitations of REIMS include logistical challenges and the complexity of data interpretation, necessitating further in vivo research.

  • 5

    The review highlights the need for standardized, rapid diagnostic methods in surgery to improve intraoperative decision-making.

Original Source(s)

Rapid evaporative ionization mass spectrometry in surgery: a systematic review

  • by Angus R J Barber, Alexander Dottore, James Leigh, Mark Fear, Fiona Wood

  • November 12, 2025

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