Elastography Distinguishes Cardiac Amyloidosis Types
Shear wave velocity measurements in the basal anteroseptal and right ventricular walls differed between transthyretin and light chain cardiac amyloidosis when conventional echocardiographic parameters did not.
By
Kathryn Wighton
June 28, 2026
1
A study of 72 patients assessed myocardial stiffness using three-dimensional shear wave elastography alongside other diagnostic methods.
2
The two primary forms of cardiac amyloidosis are light chain and transthyretin cardiac amyloidosis, differing in disease progression and treatment.
3
Shear wave velocity was higher in patients with transthyretin cardiac amyloidosis compared to those with light chain cardiac amyloidosis.
4
An algorithm combining patient age, N-terminal pro-B-type natriuretic peptide, and shear wave velocity achieved 100% sensitivity and specificity.
5
The study suggests that three-dimensional shear wave elastography may effectively distinguish between types of cardiac amyloidosis.
