Modulation of chemokine secretion and oxidative stress in vitro in thyroid cells after exposure to thiocyanate, nitrate, or perchlorate - Takeaways - MDSpire

Modulation of chemokine secretion and oxidative stress in vitro in thyroid cells after exposure to thiocyanate, nitrate, or perchlorate

  • By

  • Alessia Greco

  • Francesca Coperchini

  • Elena Franchi

  • Marco Denegri

  • Laura Croce

  • Marsida Teliti

  • Vincenzo Marotta

  • Flavia Magri

  • Giuseppina De Marco

  • Eleonora Ferrarini

  • Luisa Pignata

  • Patrizia Agretti

  • Massimo Tonacchera

  • Mario Rotondi

  • May 22, 2026

  • 0 min

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  • 1

    Perchlorate, nitrate, and thiocyanate are thyroid disruptors that affect oxidative stress and chemokine release in thyroid cells.

  • 2

    Thiocyanate reduced viability in TPC-1 cells but did not significantly affect normal human thyroid or 8505C cells.

  • 3

    Perchlorate increased reactive oxygen species (ROS) production in normal thyroid cells, while thiocyanate decreased ROS in TPC-1 cells.

  • 4

    Thiocyanate consistently increased CXCL8 secretion in a concentration-dependent manner, while nitrate and perchlorate had minimal effects.

  • 5

    The study suggests that thiocyanate may promote a pro-inflammatory thyroid microenvironment, potentially favoring tumor development.

Original Source(s)

Modulation of chemokine secretion and oxidative stress in vitro in thyroid cells after exposure to thiocyanate, nitrate, or perchlorate

  • by Alessia Greco, Francesca Coperchini, Elena Franchi, Marco Denegri, Laura Croce, Marsida Teliti, Vincenzo Marotta, Flavia Magri, Giuseppina De Marco, Eleonora Ferrarini, Luisa Pignata, Patrizia Agretti, Massimo Tonacchera, Mario Rotondi

  • May 22, 2026

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