36 genes may reshape OCD, tic genetics - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

36 genes may reshape OCD, tic genetics

Whole-exome sequencing identifies large-effect risk genes across obsessive-compulsive and chronic tic disorders, with most supported by both conditions.

  • By

  • Andrea Surnit

  • September 2, 2026

  • 3 min

Share

  • 1

    Researchers identified 36 high-confidence risk genes linked to obsessive-compulsive disorder (OCD) and chronic tic disorders (CTDs).

  • 2

    The study analyzed whole-exome sequencing data from 3,964 patients, including parent-proband trios and singletons.

  • 3

    A total of 12 high-confidence risk genes were identified for OCD and 10 for CTDs, with 34 genes overlapping between the two disorders.

  • 4

    Approximately 7% to 8% of patients with OCD and/or CTDs carried at least one risk-contributing de novo damaging variant.

  • 5

    The findings suggest substantial genetic overlap between OCD and CTDs, with implications for shared neurobiological features.

Original Source(s)

36 genes may reshape OCD, tic genetics

  • by Andrea Surnit

  • September 2, 2026

Related Content

Beyond Theory of Mind: mentalization as a relational and developmental framework for autism

Can SGLT2 Inhibitors Affect Dementia?

A target trial emulation using Veterans Affairs electronic health records examined neuropsychiatric outcomes associated with SGLT2 inhibitor use.

RITA-T (rapid interactive screening test for autism in toddlers): a scoping review of psychometric properties, cross-cultural validation, and clinical applications