Higher admission serum total carbon dioxide is independently associated with early seizure recurrence in children with benign convulsions with mild gastroenteritis - Takeaways - MDSpire

Higher admission serum total carbon dioxide is independently associated with early seizure recurrence in children with benign convulsions with mild gastroenteritis

  • By

  • Ling Zou

  • Feng Li

  • Hongyu Li

  • Zhihong Su

  • June 16, 2026

  • 0 min

Share

  • 1

    Higher admission serum total carbon dioxide (TCO2) levels are linked to increased risk of early seizure recurrence in pediatric patients with benign convulsions.

  • 2

    In a study of 86 children, 26.7% experienced seizure recurrence within 48 hours, with median TCO2 significantly higher in the recurrence group.

  • 3

    Multivariable analysis showed that higher TCO2 and younger age were independently associated with seizure recurrence, with an odds ratio of 1.235 for TCO2.

  • 4

    A TCO2 cutoff of 16.25 mmol/L demonstrated 78.3% sensitivity and 61.9% specificity for predicting seizure recurrence.

  • 5

    The study suggests that TCO2 may serve as a practical biomarker for risk stratification in children with benign convulsions associated with mild gastroenteritis.

Original Source(s)

Higher admission serum total carbon dioxide is independently associated with early seizure recurrence in children with benign convulsions with mild gastroenteritis

  • by Ling Zou, Feng Li, Hongyu Li, Zhihong Su

  • June 16, 2026

Related Content

Early-onset rice body synovitis of the knee in children under three years: a case series and review of the literature

FDA Approves Low-Dose Macrocyclic Contrast Agent for MRI

The macrocyclic gadolinium-based contrast agent has a recommended dose of 0.01 mmol/kg actual body weight.

Extent of the low-density line is associated with time to fracture in children with congenital anterolateral bowing of the tibia: a retrospective survival analysis