Elevated serum total carbon dioxide levels at admission are linked to increased risk of early seizure recurrence in pediatric patients with benign convulsions associated with mild gastroenteritis

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Higher admission serum total carbon dioxide (TCO2) levels are linked to increased risk of early seizure recurrence in pediatric patients with benign convulsions.
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In a study of 86 children, 26.7% experienced seizure recurrence within 48 hours, with median TCO2 significantly higher in the recurrence group.
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Multivariable analysis showed that higher TCO2 and younger age were independently associated with seizure recurrence, with an odds ratio of 1.235 for TCO2.
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A TCO2 cutoff of 16.25 mmol/L demonstrated 78.3% sensitivity and 61.9% specificity for predicting seizure recurrence.
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The study suggests that TCO2 may serve as a practical biomarker for risk stratification in children with benign convulsions associated with mild gastroenteritis.

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