Calcium signaling in psoriasis: from pathogenesis to therapeutic opportunities - Takeaways - MDSpire

Calcium signaling in psoriasis: from pathogenesis to therapeutic opportunities

  • By

  • Y. X. Chen

  • D. X. Zhuo

  • F. F. Wang

  • July 15, 2026

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  • 1

    Psoriasis is a chronic inflammatory skin disease driven by the IL-23/IL-17 inflammatory axis, affecting keratinocyte proliferation and immune balance.

  • 2

    Calcium signaling plays a critical role in keratinocyte differentiation and immune cell activation, influencing the pathogenesis of psoriasis.

  • 3

    Dysregulation of calcium signaling in keratinocytes leads to impaired differentiation and skin barrier dysfunction, contributing to psoriasis.

  • 4

    Persistently activated calcium signaling in immune cells promotes Th17 polarization and amplifies inflammation through specific downstream pathways.

  • 5

    The review proposes that compartment-specific bidirectional calcium dysregulation is a key pathological feature in psoriasis, affecting both epidermal and immune compartments.

Original Source(s)

Calcium signaling in psoriasis: from pathogenesis to therapeutic opportunities

  • by Y. X. Chen, D. X. Zhuo, F. F. Wang

  • July 15, 2026

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