A Ten-Year Analysis of Receptor Variability and Phenotypic Changes in Metastatic Breast Cancer: Insights from a Retrospective Study of 363 Cases at a Single Institution - Takeaways - MDSpire

A Ten-Year Analysis of Receptor Variability and Phenotypic Changes in Metastatic Breast Cancer: Insights from a Retrospective Study of 363 Cases at a Single Institution

  • By

  • Sijie Chen

  • Qianqian Sun

  • Li Yan

  • Jiao Yang

  • Jin Yang

  • April 20, 2026

  • 0 min

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  • 1

    This study analyzed 436 paired samples of primary and metastatic breast cancer to assess receptor variability and its impact on prognosis.

  • 2

    Receptor discordance rates were 25.1% for ER, 33.3% for PR, and 32.8% for HER2, with PR showing the highest transition from positive to negative.

  • 3

    Loss of hormone receptor or HER2 expression was linked to poorer overall survival, while sustained positivity improved survival outcomes.

  • 4

    HER2 discordance was notably highest in liver metastases, indicating specific metastatic sites may influence receptor variability.

  • 5

    Reassessment of receptor status in metastatic lesions is crucial for optimizing individualized treatment strategies in metastatic breast cancer.

Original Source(s)

A Ten-Year Analysis of Receptor Variability and Phenotypic Changes in Metastatic Breast Cancer: Insights from a Retrospective Study of 363 Cases at a Single Institution

  • by Sijie Chen, Qianqian Sun, Li Yan, Jiao Yang, Jin Yang

  • April 20, 2026

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